Marcus Rashford has not travelled with the Manchester United squad for their Europa League clash with Sheriff Tiraspol on Thursday.
The 24-year-old, who has started the campaign in promising fashion for United, will stay at home, along with Anthony Martial, Donny van de Beek and Aaron Wan-Bissaka.
None of the quartet trained at Carrington on Wednesday morning ahead of the flight to Moldova.
Erik ten Hag is otherwise taking a full strength squad, with Cristiano Ronaldo among the travelling party and Luke Shaw returning after injury.
United are looking for their first points of their Group E campaign, having lost to Real Sociedad last week.
Ten Hag will face the media on Wednesday tea-time to preview the fixture.